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The cause is unknown, although breast feeding may be related.

It is unknown whether the inflammatory process proceeds or follows the dilatation of the duct.

Nipple discharge is the third most common complaint among women after breast pain or a breast mass.

Up to 50% of women in their reproductive years can express one or more drops of fluid from the breast. Nevertheless, it does raise the concern about two uncommon but serious conditions. Common Features: • Unilateral or bilateral discharge • Cycle variation • Induced or spontaneous discharge • Discharge may be clear, serous, milky, yellow, green, pink or slightly bloody, brown or black (old blood) • Discharge may originate from one or multiple ducts Normal/Benign Discharge: During pregnancy and up to two years after delivery nipple discharge is normal and milky in nature.

The breast is a secretory gland that responds to the stimulation of different hormones, including estrogen and progesterone.

These hormones are responsible for controlling breast development during puberty.

The incidence of breast cancer associated to isolated nipple discharge ranges from .6% to 2%.

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The incidence goes up to 9% in patients older than 50 years of age. ductal, lobular, tubular, and medullary) are sometimes diagnosed as a result of nipple discharge.

Special attention should be given to papillary carcinoma, despite it being a rare malignancy ( The appropriate treatment should be based on the specific condition causing the abnormal nipple discharge.

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